CHEMICAL CONSTITUENTS AND ACETYLCHOLINESTERASE ACTIVITY FROM Polyalthia sumatrana (Miq.) Kurz

Authors

  • Wan Mohd Nuzul Hakimi Wan Salleh ​Department of Chemistry Faculty of Science and Mathematics Universiti Pendidikan Sultan Idris
  • Natasa Mohd Shakri
  • Mohd Azlan Nafiah
  • Shamsul Khamis

DOI:

https://doi.org/10.52292/j.laar.2022.852

Keywords:

Annonaceae, Polyalthia sumatrana, alkaloid, acetyl-cholinesterase, Alzheimer

Abstract

This study was carried out to investigate the phytochemicals from Polyalthia sumatrana and their acetylcholinesterase inhibitory activity. Fractionation and purification of the leaves of P. sumatrana led to the isolation and identification of five alkaloids; boldine (1), norboldine (2), liriodenine (3), predicentrine (4), laurotetanine (5) together with β-sitosterol (6), β-sitostenone (7), vanillin (8), vanillic acid (9) and cinnamic acid (10). The structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that all isolated alkaloids were found to inhibit AChE with percentage inhibition values ranged from 45.0 to 80.6%.

Published

2022-01-01