Improvement of dissolution rate of ticagrelor gastro-retentive tablets using HPMC and PEO
DOI:
https://doi.org/10.52292/j.laar.2025.3449Keywords:
Dissolution, Gastro-retentive tablet, Hydroxypropyl methylcellulose, Polyethylene oxide, TicagrelorAbstract
This study aimed to develop ticagrelor (TCG) gastro-retentive (GR) tablets with improved dissolution rates by exploiting the swelling property of the polymer. Seven formulations were identified by adjusting the ratio of hydroxypropyl methylcellulose (HPMC) to polyethylene oxide (PEO) and swelling and dissolution tests were performed. Formulation A1, comprising PEO alone, had a high swelling rate of 104.68 %; however, the dissolution rate (f2=36.39) was low because of the sustained-release function of PEO. Formulation A2, comprising HPMC alone, dissolved without maintaining the tablet form, with a very high dissolution rate (f2=25.92). Therefore, the two polymers were deemed suitable to be included at an appropriate ratio. Formulation B5, which dissolved while maintaining the tablet form and exhibited an appropriate swelling rate (119.43 %) and dissolution rate (f2=62.08), was deemed suitable as a TCG GR tablet. This study confirmed the swelling of TCG GR tablets and gastric residence time in vitro.
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