EFFECT OF THE IBUPROFEN SOLUBILITY IN ACETONE AND DICHLOROMETHANE ON THE DRUG RELEASE PROFILES FROM PLGA MICROSPHERES
Acetone and dichloromethane were used as organic solvent to prepare ibuprofen-loaded PLGA microspheres by the emulsion-solvent evaporation method. Some microspheres properties, such as microencapsulation efficiency and particle size, were affected by the organic solvent used. Depending on the organic solvent used microparticles obtained exhibited different controlled release profiles. In all cases it was extended up to 15 days. The obtained formulations did not exhibit zero- or first-order release kinetics and non-agreement with the Higuchi or Korsmeyer-Peppas models was found. On the other hand, the model proposed by Gallagher and Corrigan for PLGA systems described fully the drug dissolution processes from the microspheres obtained. A relationship between the ibuprofen solubility in both organic solvents studied and some parameters estimated for the dissolution model of the microparticles prepared with these solvents was also found. Thus, it could be propose that the drug solubility in different organic solvents affects the physical characteristics of microparticles and their dissolution profiles.
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